Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Venofer may cause clinically significant hypotension. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] Monitor for signs and symptoms of hypotension following each administration of Venofer. Applies only to oral form of both agents. Applies only to oral form of both agents. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. Minor/Significance Unknown. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Modify Therapy/Monitor Closely. PDF Venofer - Food and Drug Administration Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Applies only to oral form of both agents. Consult your pharmacist or local waste disposal company. Kumpf VJ, Holland EG. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. This may be helped by giving the medication more slowly or at a lower dose. Venofer (iron sucrose) dose calculator | Calculosaurus.com Use Caution/Monitor. informational and educational purposes only. (See also Notes section. . . Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? Canada residents can call a provincial poison control center. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Applies only to oral form of both agents. 1974 Jun;31(6):592-5. Contact the applicable plan sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Fatal reactions have also occurred in situations where the test dose was tolerated. Applies only to oral form of both agents. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Drug Des Devel Ther; 5: 5160. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. Anemia caused by the depletion of iron is called iron deficiency anemia. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. Use Caution/Monitor. May increase risk of hypotension. Venofer treatment may be repeated if necessary. Total dose iron infusion: safety and efficacy in predialysis patients. 1) Ganzoni AM. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. Avoid or Use Alternate Drug. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. Applies only to oral form of both agents. Applies only to oral form of both agents. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Interaction only with oral iron administration. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. commonly, these are "non-preferred" brand drugs. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Most Applies only to oral form of both agents. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Minor (1)iron sucrose, benazepril. 2000 Jan;22(1):39-43. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. Otherwise, call a poison control center right away. Ferric carboxymaltose (Ferinject) for iron-deficiency anaemia The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. Applies only to oral form of both agents. Access your plan list on any device mobile or desktop. Use Caution/Monitor. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Copyright 1993-2021 Discuss the risks and benefits with your doctor.This medication passes into breast milk. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Monitor for signs and symptoms of hypotension following each Feraheme infusion. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Use Caution/Monitor. Interaction only with oral iron administration. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . Applies only to oral form of both agents. Avoid or Use Alternate Drug. Our dosage calculator can help you with this as well. In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. Applies only to oral form of both agents. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. Avoid or Use Alternate Drug. I. 1988 May;111(5):566-70. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Iron Sucrose - Injection - Alberta Applies only to oral form of both agents. Avoid or Use Alternate Drug. Do not administer Venofer to patients with evidence of iron overload. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Am J Hosp Pharm. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. Anemia; 2015: 763576. Share cases and questions with Physicians on Medscape consult. Applies only to oral form of both agents. View the formulary and any restrictions for each plan. Your list will be saved and can be edited at any time. Applies only to oral form of both agents. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. https://www.uptodate.com/ (Requires subscription). VENOFER (IRON SUCROSE INJECTION,USP) 100mg ELEMENTAL IRON - DailyMed Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Oral and parenteral products - see background option for oral products. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Last updated on Jun 1, 2022. Venofer treatment may be repeated if necessary. Last updated 28/06/2018 Enter values here and press 'Calculate'. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Observed Hb = the patients current hemoglobin in g/dl. 1 Dosing for patients who weigh less than 50 kg Do Not Copy, Distribute or otherwise Disseminate without express permission. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. 5. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. Applies only to oral form of both agents. Intravenous iron-dextran: therapeutic and experimental possibilities. Pain, swelling, or redness at the injection site may occur. Perinatology and Obstetrical Calculators Separate dosing of tetracyclines from these products. 2010;18(3). aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Minor/Significance Unknown. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. Nutrition. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. Parenteral iron supplementation. Use Caution/Monitor. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. World J Gastroenterol; 16(22): 27202725. Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. Minor/Significance Unknown. Medically reviewed by Drugs.com. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Test Dose: Not required. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. 2.1 . Administer Venofer early during the dialysis session (generally within the first hour). This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. This drug is available at a higher level co-pay. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. DailyMed - VENOFER- IRON SUCROSE injection, solution The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Iron Sucrose (Ferogen): Indications, Dosage, Administration - Medcrine iron sucrose, benazepril. Many patients with kidney disease cannot get enough iron from food and require injections. Applies only to oral form of both agents. iron sucrose increases levels of calcium carbonate by enhancing GI absorption. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Although the original formula requires the weight in kilograms, values input in lbs are transformed. Applies only to oral form of both agents. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. Am J HealthSyst Pharm 2006;63:731735. LBW = Lean body weight in kg. Applies only to oral form of both agents. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Use Caution/Monitor. FERAHEME met the predefined criteria for non-inferiority to Venofer . Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Maximum recommended single dose: 300 mg (See Prescriber's Orders). Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. . gymnema decreases levels of iron sucrose by inhibition of GI absorption. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Monitor Closely (1)trientine, iron sucrose. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. Dosing and Infusion Rates - PRIVIGEN vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Iron deficiency anemia is the type of anemia caused by iron depletion. ]Venofer treatment may be repeated if iron deficiency reoccurs. Creating an account is free and takes less than 1 minute. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. This website is intended for use by US healthcare professionals only. The dosage of Venofer is expressed in mg of elemental iron. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL however iron sucrose requires multiple small intermittent doses over days to weeks. The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated.
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